Bioavailability of paracetamol and ibuprofen in single and combination dosage in rabbits

synthase thereby permitting an abnormal buildup of excitatory neurotransmitter glutamic acid. Both GBP and CBZ significantly decreased (P<0.05) the serum TBARS concentration as compared to the PTX-treated group. SERT pretreatment resulted in a highly significant increase in serum TBARS when compared with normal control (P<0.01) as well as with PTXtreated group (P<0.05). This effect further substantiates the proconvulsive effect of SERT. A combination of CBZ+SERT and GBP+SERT showed TBARS levels almost equal to the PTXtreated group but the serum TBARS levels were significantly higher than the CBZ alone and GBP alone groups respectively. These findings correspond to the SERT potential of diminishing the anticonvulsant activities of CBZ and GBP. The management of epilepsy is a difficult task because of associated neuropsychiatric disorders among which depression being highly reported. Quite often epileptic patients have to be prescribed antidepressants along with anticonvulsants in order to treat the accompanying depression. SSRIs, especially SERT, is frequently given along with anticonvulsant drugs. However, the use of SERT in epileptics is questioned because of the proconvulsive effect of SSRI. The present study clearly demonstrates the proconvulsive and prooxidant activity of SERT when given in combination with CBZ and GBP. However, our findings are preliminary and further studies involving different oxidative stress parameters are needed for confirmation.